abstract：:Only recently have the studies of yeast ageing started to focus on the S288c-derived strains used extensively in genomics and on the longest lifespans. Chronological longevity (stationary (G(0)) survival) of such strains is greater when cells are pre-grown on a respiratory carbon source, as compared to when they are p...

journal_title：Mechanisms of ageing and development

authors： Piper PW,Harris NL,MacLean M

更新日期：2006-09-01 00:00:00

abstract：:Hutchinson-Gilford Progeria syndrome (HGPS) is a rare genetic disorder that displays features of segmental aging. It is manifested predominantly in connective tissue, with most prominent histological changes occurring in the skin, cartilage, bone and cardiovascular tissues. Detailed quantitative real time reverse-tran...

journal_title：Mechanisms of ageing and development

authors： Lemire JM,Patis C,Gordon LB,Sandy JD,Toole BP,Weiss AS

更新日期：2006-08-01 00:00:00

abstract：:BCL-2 functions as a death repressor molecule in an evolutionary conserved cell death pathway. Inactivation of bcl-2 in mice results in pleiotropic effects including postnatal growth retardation, massive apoptosis in lymphoid tissues, polycystic kidney disease (PKD) and shortened lifespan. To evaluate the influence of...

journal_title：Mechanisms of ageing and development

authors： Fedorov LM,Schmittwolf C,Amann K,Thomas WH,Müller AM,Schubert H,Domen J,Kneitz B

更新日期：2006-07-01 00:00:00

abstract：:Compelling evidence supports the importance of metabolic abnormalities in Alzheimer disease pathogenesis. Indeed, that oxidative mechanisms are involved in the neuropathology associated with Alzheimer disease is evidenced by the large number of metabolic signs of oxidative stress as well as by specific markers of oxid...

journal_title：Mechanisms of ageing and development

authors： Moreira PI,Zhu X,Lee HG,Honda K,Smith MA,Perry G

更新日期：2006-06-01 00:00:00

abstract：:Dietary factors have a profound effect on many aspects of health including ageing and do so, at least partly, through interactions with the genome which result in altered gene expression. The application of high throughput genomics technologies in nutritional research (nutrigenomics) offers a new approach to understan...

journal_title：Mechanisms of ageing and development

authors： Mathers JC

更新日期：2006-06-01 00:00:00

abstract：:This study attempts to elucidate the molecular mechanisms underlying the ageing-dependent cAMP profiles in human diploid fibroblasts stimulated by lysophosphatidic acid (LPA). In senescent cells, LPA-dependent Gialpha activation was reduced, with a consequent reduction in Gi-suppressed cAMP levels, without alterations...

journal_title：Mechanisms of ageing and development

authors： Jang IS,Rhim JH,Kim KT,Cho KA,Yeo EJ,Park SC

更新日期：2006-05-01 00:00:00

abstract：:Ceramide mediates the effects of several agonists leading to differentiation, apoptosis or senescence. We previously showed that ceramide becomes elevated in senescent fibroblasts. In the present study, senescent cultures of Wi-38 fibroblasts and human umbilical-vein endothelial cells were compared to low-passage cult...

journal_title：Mechanisms of ageing and development

authors： Venable ME,Webb-Froehlich LM,Sloan EF,Thomley JE

更新日期：2006-05-01 00:00:00

abstract：:There is now strong evidence implicating the generation of reactive oxygen species (ROS) and the corresponding response to oxidative stress as key factors in the pathogenesis of several human diseases including cancer, atherosclerosis, and neurodegenerative disorders, and in ageing. The carcinogenicity of oxidative st...

journal_title：Mechanisms of ageing and development

authors： Lee KW,Lee HJ

更新日期：2006-05-01 00:00:00

abstract：:Mutated huntingtin is expressed in nervous and non nervous system included lymphoblasts. Eneregetic metabolism is impaired in Huntington's disease (HD) and other neurodegenerative diseases. Human HD lymphoblasts have provided clear-cut data on mitochondnal disruption. Here we report morphological, morphometric and mem...

journal_title：Mechanisms of ageing and development

authors： Squitieri F,Cannella M,Sgarbi G,Maglione V,Falleni A,Lenzi P,Baracca A,Cislaghi G,Saft C,Ragona G,Russo MA,Thompson LM,Solaini G,Fornai F

更新日期：2006-02-01 00:00:00

abstract：:The conserved SIR2 protein regulates life span in both yeast and worms: in both organisms overexpression of SIR2 can extend life span and in Caenorhabditis elegans this life span extension is dependent on the forkhead transcription factor, DAF-16. Here, we have done extensive genetic analysis with sir-2.1(ok434), a nu...

journal_title：Mechanisms of ageing and development

authors： Wang Y,Tissenbaum HA

更新日期：2006-01-01 00:00:00

abstract：:In recent years, there was an increasing interest on candidate genes may play an important role in the development of Alzheimer's disease (AD). Several genome wide screens have undertaken so far or expanded recently, and suggested a number of genomic areas that may contain novel susceptibility genes for AD, in particu...

journal_title：Mechanisms of ageing and development

authors： Panza F,Colacicco AM,D'Introno A,Capurso C,Liaci M,Capurso SA,Capurso A,Solfrizzi V

更新日期：2006-01-01 00:00:00

abstract：:Previous studies have suggested a possible relationship between the ubiquitin-proteasome pathway and some pathological manifestations of Alzheimer's disease (AD). This study investigated the possibility that the Abeta peptides interact with the ubiquitin-proteasome pathway inside neuronal cells. The ubiquitin-proteaso...

journal_title：Mechanisms of ageing and development

authors： Oh S,Hong HS,Hwang E,Sim HJ,Lee W,Shin SJ,Mook-Jung I

更新日期：2005-12-01 00:00:00

abstract：:There is currently of a great interest investigating the role of nutrition in the prevention of age-associated disorders. The present study aimed to evaluate, on a particular strain of mice, the efficacy of alternate-day fasting on the mitochondrial production of free radical species and on the incidence of a specific...

journal_title：Mechanisms of ageing and development

authors： Descamps O,Riondel J,Ducros V,Roussel AM

更新日期：2005-11-01 00:00:00

abstract：:The peripheral-type benzodiazepine receptor (PBR) is a protein predominantly located in the mitochondrial outer membrane that plays an important role in the regulation of cell survival and proliferation. Previous studies have shown an enhanced expression of PBR in the regenerating sciatic nerve, suggesting that this p...

journal_title：Mechanisms of ageing and development

authors： Leonelli E,Yague JG,Ballabio M,Azcoitia I,Magnaghi V,Schumacher M,Garcia-Segura LM,Melcangi RC

更新日期：2005-11-01 00:00:00

abstract：:The human premature aging protein Werner (WRN), deficient in Werner syndrome (WS), is localized mainly to the nucleolus in many cell types. DNA damage or replication arrest causes WRN to redistribute from the nucleolus to the nucleoplasm into discrete foci. In this study, we have investigated DNA damage specific cellu...

journal_title：Mechanisms of ageing and development

authors： Karmakar P,Bohr VA

更新日期：2005-11-01 00:00:00

abstract：:The lifespan of the nematode, Caenorhabditis elegans, can be extended by mutations affecting components of the insulin-like growth factor (IGF) signaling cascade or by overexpression of SIR2, an NAD+-dependent protein deacetylase. The mammalian homologue of SIR2, Sirt1, has been shown to modulate the activity of FoxO,...

journal_title：Mechanisms of ageing and development

authors： Lemieux ME,Yang X,Jardine K,He X,Jacobsen KX,Staines WA,Harper ME,McBurney MW

更新日期：2005-10-01 00:00:00

abstract：:Mitochondrial reactive oxygen species (ROS) and oxidative damage are associated with a range of age-related human pathologies. It is also likely that mitochondrial ROS generation is a factor in stress response and signal transduction pathways. However, current methods for measuring and influencing mitochondrial ROS pr...

journal_title：Mechanisms of ageing and development

authors： James AM,Cochemé HM,Murphy MP

更新日期：2005-09-01 00:00:00

abstract：:Aging is a complex physiological process by which the functions of many organ systems deteriorate. Growing evidence shows that age-related changes and damage are causally related to oxidative stress and inflammatory responses from reactive species. The aim of this study was to identify differentially expressed genes i...

journal_title：Mechanisms of ageing and development

authors： Sung B,Jung KJ,Song HS,Son MJ,Yu BP,Chung HY

更新日期：2005-08-01 00:00:00

abstract：:To further explore whether immune function and acute phase response are altered during ageing, the response to a mild inflammatory stress (DT-Polio-Typhim vaccination) was studied in elderly and young subjects. Cytokine production (IFN-gamma, TNF-alpha, IL-6, IL-10) by whole blood cultures, circulating cytokines and a...

journal_title：Mechanisms of ageing and development

authors： El Yousfi M,Mercier S,Breuillé D,Denis P,Papet I,Mirand PP,Obled C

更新日期：2005-08-01 00:00:00

abstract：:Patients with X-linked lymphoproliferative syndrome (XLP) experience excessive T cell proliferation after primary Epstein-Barr virus (EBV) infection, due to mutations in the signalling lymphocyte activation molecule (SLAM) associated protein (SAP) molecule. We examined the impact of dysfunctional proliferative control...

journal_title：Mechanisms of ageing and development

authors： Plunkett FJ,Franzese O,Belaramani LL,Fletcher JM,Gilmour KC,Sharifi R,Khan N,Hislop AD,Cara A,Salmon M,Gaspar HB,Rustin MH,Webster D,Akbar AN

更新日期：2005-08-01 00:00:00

abstract：:We have isolated a new type of Paramecium tetraurelia mutant, named rie-2, that has a long immaturity period until autogamy. We previously isolated such an autogamy mutant, designated rie-1. These two mutants had some additional common features such as dependence of the occurrence of autogamy on the temperature, invol...

journal_title：Mechanisms of ageing and development

authors： Komori R,Sato H,Harumoto T,Takagi Y

更新日期：2005-06-01 00:00:00

abstract：:A major cause of ageing is thought to be the accumulation of damage to macromolecules. Accumulation to DNA damage in cells therefore presupposes that aged cells are unable to repair this damage. We have used the in vitro model of cellular ageing to test the idea that senescent cells are deficient in some aspect of DNA...

journal_title：Mechanisms of ageing and development

authors： Al-Baker EA,Oshin M,Hutchison CJ,Kill IR

更新日期：2005-06-01 00:00:00

abstract：:We investigated mitochondrial ageing in a temperate (Mya arenaria) and an Antarctic (Laternula elliptica) mud clam, with similar lifestyle (benthic filter feeders) but different maximum life spans (MLSP), 13 and 36 years, respectively. The short-lived temperate M. arenaria showed a more pronounced decrease in mitochon...

journal_title：Mechanisms of ageing and development

authors： Philipp E,Pörtner HO,Abele D

更新日期：2005-05-01 00:00:00

abstract：:During senescence, autofluorescent lysosomal storage bodies known as lipofusin or age pigment accumulate in many post-mitotic types of cells. Among these cell types is the retinal pigment epithelium (RPE) of the mammalian eye. The mechanisms of lipofuscin formation and accumulation have been studied more extensively i...

journal_title：Mechanisms of ageing and development

authors： Katz ML,Wendt KD,Sanders DN

更新日期：2005-04-01 00:00:00

abstract：:Classical evolutionary theory predicts the existence of genes with antagonistic effects on longevity and various components of early-life fitness. Quantitative genetic studies have provided convincing evidence that such genes exist. However, antagonistic pleiotropic effects have rarely been attributed to individual lo...

journal_title：Mechanisms of ageing and development

authors： Leroi AM,Bartke A,De Benedictis G,Franceschi C,Gartner A,Gonos ES,Fedei ME,Kivisild T,Lee S,Kartaf-Ozer N,Schumacher M,Sikora E,Slagboom E,Tatar M,Yashin AI,Vijg J,Zwaan B

更新日期：2005-03-01 00:00:00

abstract：:The aim of this study was to investigate the effect of physical training on balance, strength, and general well-being in adult people with intellectual disability (ID). This study evaluated how physical training can effect physical and psychological change among 'older' adults with mild ID. Participants consisted of n...

journal_title：Mechanisms of ageing and development

authors： Carmeli E,Zinger-Vaknin T,Morad M,Merrick J

更新日期：2005-02-01 00:00:00

abstract：:Understanding mechanisms underlying longevity, and endeavor towards the specific goals of alleviating frailty in old age, require a comprehensive approach that considers the various theoretical and experimental approaches, as well as compiling the data on humans. This logistic has underlined the program of the confere...

journal_title：Mechanisms of ageing and development

authors： Globerson A,Barzilai N

更新日期：2005-02-01 00:00:00

abstract：:Longevity regulatory genes include the Forkhead transcription factor FOXO, in addition to NAD-dependent histone deacetylase silent information regulator 2 (Sir2). The FOXO/DAF-16 family of transcription factors constitute an evolutionarily conserved subgroup within a larger family known as winged helix or Forkhead tra...

journal_title：Mechanisms of ageing and development

authors： Xuan Z,Zhang MQ

更新日期：2005-01-01 00:00:00

abstract：:Many molecular chaperones are also known as heat shock proteins because they are synthesised in increased amounts after brief exposure of cells to elevated temperatures. They have many cellular functions and are involved in the folding of nascent proteins, the re-folding of denatured proteins, the prevention of protei...

journal_title：Mechanisms of ageing and development

authors： Proctor CJ,Soti C,Boys RJ,Gillespie CS,Shanley DP,Wilkinson DJ,Kirkwood TB

更新日期：2005-01-01 00:00:00

abstract：:Restriction of food intake extends lifespan in evolutionarily diverse organisms, including mammals. Dietary restriction (DR) also delays the appearance of ageing-related damage and pathology and keeps organisms in a youthful state for longer. DR has hence been suggested to lower the rate of ageing. Analysis of mortali...

journal_title：Mechanisms of ageing and development

authors： Partridge L,Pletcher SD,Mair W

更新日期：2005-01-01 00:00:00

abstract：:The oral health of older people is changing with reducing numbers of people relying on complete dentures for function, and retaining some natural teeth. Despite this there are substantial numbers of older people whose ability to chew foods is compromised by their oral health status, either because they have few or no ...

journal_title：Mechanisms of ageing and development

authors： Walls AW,Steele JG

更新日期：2004-12-01 00:00:00

abstract：:Chronic oxidative stress is generally believed to be a major etiologic factor in the aging process. In addition to modulation of signaling processes and oxidation of cellular proteins and lipids, reactive oxygen species (ROS) induce multiple damages in both nuclear and mitochondrial genomes, most of which are repaired...

journal_title：Mechanisms of ageing and development

authors： Szczesny B,Bhakat KK,Mitra S,Boldogh I

更新日期：2004-10-01 00:00:00

abstract：:We tested the hypothesis that Ca(2+)-activated myosin ATPase activity is lower in muscles of aged rats relative to muscles of young rats, independent of changes in myosin isoform expression. Myofibrils were prepared from permeabilized fibers of soleus, plantaris, and semimembranosus muscles of young (8-12 months) and ...

journal_title：Mechanisms of ageing and development

authors： Lowe DA,Husom AD,Ferrington DA,Thompson LV

更新日期：2004-09-01 00:00:00

abstract：:To gain insight into the anti-ageing mechanisms of caloric restriction (CR), liver mitochondria were isolated from male Brown-Norway rats of different ages (fully fed control and CR) and various specific markers of non-enzymatic protein modification (by oxidative, glyco- and lipoxidative-reactions) were measured by GC...

journal_title：Mechanisms of ageing and development

authors： Lambert AJ,Portero-Otin M,Pamplona R,Merry BJ

更新日期：2004-08-01 00:00:00

abstract：:The purpose of the present study was to investigate the effect of aging on silica-induced lung toxicity. In young animals silica induced a significant increase in bronchoalveolar lavage tumor necrosis factor-alpha (TNF), lactate dehydrogenase as well as in cell numbers, which correlate with increased collagen depositi...

journal_title：Mechanisms of ageing and development

authors： Corsini E,Giani A,Peano S,Marinovich M,Galli CL

更新日期：2004-02-01 00:00:00

abstract：:Aging and HIV disease show certain immunological similarities. In both situations, control over viral infection is diminished, and there is an increase in certain types of cancer. The immune cell type responsible for controlling viral infections and cancer is the so-called CD8 or cytotoxic T cell. In elderly persons a...

journal_title：Mechanisms of ageing and development

authors： Effros RB

更新日期：2004-02-01 00:00:00

abstract：:This paper is the second one in a series of two papers hypothesizing and testing systemic grounds of reproductive life history in the female fruit fly. In the first paper, we analyzed mechanisms of individual fecundity scheduling and have drawn the following conclusions. Individual fecundity in female flies is endowed...

journal_title：Mechanisms of ageing and development

authors： Novoseltsev VN,Carey RJ,Novoseltseva JA,Papadopoulos NT,Blay S,Yashin AI

更新日期：2004-01-01 00:00:00

abstract：:Endocrine hormones are thought to be involved in processes that contribute to aging. Long-living dwarf mice are growth hormone (GH)-deficient and exhibit enhanced expression of antioxidative defense molecules when compared to normal, wild type littermates. In this study, 3- and 12-month-old Ames dwarf mice received wi...

journal_title：Mechanisms of ageing and development

authors： Brown-Borg HM,Rakoczy SG

更新日期：2003-12-01 00:00:00

abstract：:The purpose of this study was to test the hypothesis that regular exercise training in elderly people affects the type 1/type 2 balance. Nine elderly women who train by walking (mean+/-S.E.M., age 63+/-1 years, VO2 peak 32.2+/-1.0 ml kg(-1) min(-1)), 12 age-matched untrained women (63+/-1 years, 27.8+/-0.9 ml kg(-1) m...

journal_title：Mechanisms of ageing and development

authors： Ogawa K,Oka J,Yamakawa J,Higuchi M

更新日期：2003-08-01 00:00:00

abstract：:Primatologists have recognized that non-humans undergo the menopause [Biol. Reprod. 68 (2003) 10], which is preceded by years of irregular cycles and decreased fecundity. The similarity of reproductive changes between humans and baboons suggests that the aging female baboon is a particularly promising model to study h...

journal_title：Mechanisms of ageing and development

authors： Martin LJ,Carey KD,Comuzzie AG

更新日期：2003-08-01 00:00:00